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Event Info: Events
Prof. Markus Covert (Stanford University)
Prof. Markus Covert (Stanford University)

Prof. Markus Covert (Stanford University)

The E. coli whole-cell modelling project

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Time & Location

06 Dec 2023, 11:00 am – 12:00 pm

Theory of Living Systems Webinars Series

About the Event


Francis Crick first called for a coordinated worldwide scientific effort to determine a “complete solution” of the bacterium Escherichia coli. We have been working for some years now to complete a model of E. coli that takes into account all of the known functions of every well-annotated gene, in order to better understand and predict the behavior of this scientifically-relevant and industrially-significant model organism. I will discuss our ongoing efforts to improve this model, most recently with new modeling added to better describe growth rate control, transcription unit architecture and tRNA metabolism. I will then highlight our newest “whole-colony” models, a multi-scale modeling effort in which every individual within a simulated colony is running the latest version of the whole-cell model, to calculate population-level emergent behaviors based on molecular interactions and events as the colony responds to the sudden introduction of antibiotics.

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